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KMID : 0653819870130010004
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Microorganisms and Industry
1987 Volume.13 No. 1 p.4 ~ p.9
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Mechanism of E. coli RNA polymerase-promoter interactions
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Roe Jung-Hye
Record.Jr M.Thomas
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Abstract
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The regulation of gene expression in procaryotes is accomplished primarily at the level of transcription. Initiation of transcription is subject to numerous promoter-specific controls which act to ensure coordinate expression of disparate genes. The kinetics of formation of a functional("open") complex at a promoter, prior to the catalytic steps of RNA chain initiation and elongation, is thought to play a major role in controlling the efficiency of transcription of that promotor, since the subsequent processes of nucleotide binding and phosphodiester bond formation are rapid and are not promoter-specific (Mangel and Chamberlin, 1974 Shimamoto et al., 1981)
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KEYWORD
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